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Summing Up. Reducing Many Measures to a Few.

Clinical Trials Registration and Results Information Submission

Combining Measures in the Same Scale. Combining Measures with Different Scales. Treating Many Measures as a Vector. General Principles.

Federal Register :: Clinical Trials Registration and Results Information Submission

The Multivariate Normal Distribution. Nonparametric Multivariate Methods. Nearest Neighbor Tests. Projection Tests.

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The Advantages of Blocking. Methods for Classifying Patients in Blocks.

Clinical interpretation and validity of clinical trials: When do they become practice changing?

Trend Tests. Weighted Categories.

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Permutation Tests. General Comments. The Jackknife. The Bootstrap. Constructing a Restricted Test. Restricted Chi Square Tests. Normal Theory Tests. Heterogeneity of Variance. Transformations of the Data. Alternative Estimates of Variance.

Examination of Clinical Trial Costs and Barriers for Drug Development

Nonparametric Tests. Testing for Heterogeneity of Variance. Hajek Type Tests. Generalized Thompson Tests. A Litde Probability Theory. The Arguments for Bayesian Analysis. Neyman's Bayesian Derivation of Confidence Intervals. The Mean of a Normal Distribution. The Probability of a Binomial Distribution. Empirical Bayes Procedures. The Study. The Expected Results. Constructing an Overall Powerful Significance Test. The One Overall Significance Test. Alternative Methods of Analysis.


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Interval Estimates Based on Nonparametric Tests. Further Exploration. A broad range of statistical methodologies is surveyed including restricted chi-square tests, normal theory tests, nonparametric tests, permutation and resampling methods and Bayesian estimation For anyone who wants to think deeply about the basic issues involving the design and analysis of clinical trials, this book is a must read..


  • The Use of Restricted Significance Tests in Clinical Trials | David S. Salsburg | Springer.
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This ongoing revolution is not only in the physical sciences , it also touches the social sciences and even the humanities. Though profound, it is a quiet revolution that has been unnoticed by many. Macmillan Publishers website.

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